雷帕霉素靶蛋白(mTOR)通路为什么成为抗衰老研究的热点?
Why is the mTOR pathway a focus of anti-aging research?
mTOR 感知营养并调控生长,抑制它可在多种动物中延长寿命并改善健康跨度,但需权衡免疫抑制等副作用。
mTOR senses nutrients and controls growth; inhibiting it extends lifespan in many animals by shifting metabolism toward maintenance, though with side effects like immunosuppression.
难度 专业 · 适合 大众
CC BY 4.0 · 已核验 · Verified 2026-08-23 · 2 条独立证据
来源 · Source
Urry 等,《Campbell Biology》第11版,Pearson,2017
L. A. Urry et al., Campbell Biology, 11th ed., Pearson, 2017
独立核验依据 · Independent verification: 核验依据 2 ISBN 978-0-13-409341-3 (11th ed., Pearson)
#mTOR #抗衰老
细胞衰老(senescence)为什么会加速组织老化?
How does cellular senescence accelerate tissue aging?
衰老细胞停止分裂却分泌促炎因子(SASP),招来慢性炎症并干扰周围健康细胞;在老年小鼠中清除它们可改善健康。
Senescent cells stop dividing yet secrete inflammatory factors (SASP) that drive chronic inflammation and harm neighbors; clearing them improves health in aged mice.
难度 专业 · 适合 大众
CC BY 4.0 · 已核验 · Verified 2026-11-04
来源 · Source
López-Otín, Blasco, Partridge, Serrano,《The Hallmarks of Aging》,Cell,2013 (DOI: 10.1016/j.cell.2013.05.039)
López-Otín, Blasco, Partridge, Serrano, 'The Hallmarks of Aging', Cell, 2013, DOI: 10.1016/j.cell.2013.05.039
独立核验依据 · Independent verification: 核验依据 1 Crossref DOI 10.1016/j.cell.2013.05.039
#细胞衰老 #SASP
什么是炎症衰老(inflammaging)?
What is inflammaging?
随着年龄增长,体内慢性炎症水平缓慢上升,与衰老细胞和肠道菌群变化有关,被认为是多种老年病的重要推手。
Chronic low-grade inflammation rises with age, linked to senescent cells and microbiota shifts, and is a major driver of many age-related diseases.
难度 进阶 · 适合 大众
CC BY 4.0 · 来源待核验 · Source pending review
来源 · Source
出处备注:著录含书名,但缺版次 / 出版社 / 年份中的一部分,需编辑补全后才能做独立比对。
Cryan 与 Dinan,《改变心智的微生物》,《自然·神经科学评论》2012年
Cryan & Dinan, "Mind-altering microorganisms," Nature Reviews Neuroscience (2012)
#炎症衰老 #老年病
为什么少吃一点可能让人活得更长?
Why might eating a bit less help you live longer?
在营养充足但不过量的情况下,动物会调低生长信号、加强细胞修复,于是从酵母到猴子的许多物种都出现了寿命延长。
With enough but not excess food, animals dial down growth signaling and boost repair, lengthening life across species from yeast to monkeys.
难度 入门 · 适合 大众
CC BY 4.0 · 已核验 · Verified 2026-08-23 · 2 条独立证据
来源 · Source
Urry 等,《Campbell Biology》第11版,Pearson,2017
L. A. Urry et al., Campbell Biology, 11th ed., Pearson, 2017
独立核验依据 · Independent verification: 核验依据 2 ISBN 978-0-13-409341-3 (11th ed., Pearson)
#热量限制 #长寿